BDBM50041691 CHEMBL3358920::US11149292, Compound (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-
SMILES OC(=O)C[C@H]1CCc2c1[nH]c1ccc(OCc3ccc(C4CCCC4)c(c3)C(F)(F)F)cc21
InChI Key InChIKey=MVGWUTBTXDYMND-QGZVFWFLSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50041691
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Arena Pharmaceuticals
Curated by ChEMBL
Arena Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 0.0400nMAssay Description:Agonist activity at human S1P1 receptor assessed as cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Arena Pharmaceuticals
Curated by ChEMBL
Arena Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 0.102nMAssay Description:The HTRF assay was carried out using a two-step protocol essentially according to the kit manufacturer's instructions, in 20 L total volume per w...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Arena Pharmaceuticals
Curated by ChEMBL
Arena Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 6.10nMAssay Description:Agonist activity at human S1P1 receptor by beta-arrestin recruitment assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.320nMAssay Description:Agonist activity at monkey S1P1 receptor assessed as cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Canis lupus familiaris)
Arena Pharmaceuticals
Curated by ChEMBL
Arena Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 0.340nMAssay Description:Agonist activity at dog S1P1 receptor assessed as cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.320nMAssay Description:Agonist activity at rat S1P1 receptor assessed as cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Mus musculus (Mouse))
Arena Pharmaceuticals
Curated by ChEMBL
Arena Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 0.440nMAssay Description:Agonist activity at mouse S1P1 receptor assessed as cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Arena Pharmaceuticals
Curated by ChEMBL
Arena Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 1.90nMAssay Description:Induction of internalization of HA-tagged human S1P1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair